Organ in a chip

News

31/05/2018

Organ in a chip

Two Spanish researchers have created a functional model of bar inside the chip for the first time worldwide. This 3D device is capable of performing functions that the body performs in vivo. It will cost against malaria and other hematological pathologies. And it will also reduce laboratory tests with animals.

Barea is an organ of size of fist and is located on the left side of the human body under the diaphragm and behind the stomach. It works as an independent body: red pulp spreads and breaks red blood cells and bacteria, and white pulp is part of the lymphatic system. His main function is to act as a defense and to help protect our body.

The original idea of creating a blank chip was in the groups of doctors Hernando A. del Portillo and Josep Samitier. Hernando A. del Portillo CRESIB ICREA is a Professor at the ISGlobal Research Center, who has been researching the role of malaria in barley several years ago. For his part, Josep Samitier is the director of the IBEC and Professor of the University of the University of the Basque Country, researching the Rheological Properties of the Blood, which is not parasitized for malaria, to develop diagnostic systems.

"Due to the ethical and technological limitations of the study of human anatomy, which is known as the" blackbird "of the abdominal cavity, there has been very little progress in its research," says Hernando A. del Portillo, International Health Research Center of Barcelona. His team and Josep Samitierren, from the Institute of Bioengineering of Catalonia (IBEC), have been working together to simplify the study of this organ through 'systems in a chip'.

Barea on the microscale

Microscale is a device that recreates the physical properties of the organ, as if it were a real bare. The fluid system of the bar is a very convoluted and is chosen by the development to choose and break the red blood cells parasitized by old red blood cells, microorganisms and malaria.

This complex network has been able to make it look like a slow and quick channel designed to separate the emission. Including the chip, the blood goes through a slow channel that resembles a real matrix with a capillary matrix, where the percentage of red blood cells increases and the defective blood is erased.

Thanks to the multidisciplinary research team, physicists, biologists, chemists, electronic engineers and pharmacists, like the Josep Samitier team of IBEC, or Geraldine Hamilton at the Wyss Institute, have created microscopic devices that have their own living cells in a dynamic environment and another They interact with different types of cells.

In these small chips he tries to regenerate the smallest functional unit that biochemistry represents, and the mechanical functions and voltages that are perceived by the cells in the body. These devices are the result of the sharing of biomaterials that try to reproduce the mammalian mother cells and the physiological conditions at the maximum.

In a lung chip

For example, the Wyss Institute of Harvard University, Donald E. Ingber and Dongeun Huhen, has managed to design a lung in a chip. The cells used the same chances for the repetition of the same conditions in the lungs, which are the appropriate measures to place cells and their environment.

There are three internal fluid channels in the center, there is a porous membrane in the center, there are lung cells, and there are capillary cells below. The air is secreted from the upper canal and a liquid food passes through the blood microanalysis.

In addition, some mechanical forces were introduced to the chip to expand and reduce the existing membranes, to feel the same forces that arise when breathing in the lungs. "Anything that requires dynamic control, instead of static control, is a great challenge," says Takayama University of Michigan.

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Organ in a chip

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